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The regulatory effect of NRF2 on those genes was well documented through antioxidative response element binding in the promoter or enhancers of target genes

The distinct actions of Myo-Ins and Mdivi-1 indicate that the Myo-Insdependent potentiation of ATP-mediated Ca signalling does not primarily depend on mitochondrial fission inhibition, consistent with a mechanism acting at the level of PIP metabolism or IP-mediated signalling, rather than through changes in mitochondrial structure

Metabolic network analysis predicts efficacy of FDA-approved drugs targeting the causative agent of a neglected tropical disease

Sekhar RV, Patel SG, Guthikonda AP, Reid M, Balasubramanyam A, Taffet GE, Jahoor F

In the last years, several preclinical studies and clinical trials have been effectuated using different GSK-3 inhibitors, actually with few encouraging results